Primidone
پریمیدون
🧠 Nervous SystemAntiseizure (deoxybarbiturate)
Market / country: 🇺🇸 USA
Mysoline (US)
🧮 Dose calculator
Epilepsy (complex partial / absence seizures) · Regimen source: FDA Primidone · Dosage and Administration
- • Start 100–125 mg at bedtime and build over 10 days (day 4: twice, day 7: three times, day 10: 250 mg three times). Usually 750–1000 mg/day; max 500 mg four times daily. Effective serum level 5–12 µg/mL. FDA Primidone · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Porphyria; hypersensitivity to phenobarbital. FDA Primidone · Contraindications
Warnings
- • Abrupt withdrawal may precipitate status epilepticus; therapeutic efficacy takes several weeks to assess. FDA Primidone · Warnings
Formulations
- 250 mg tablet (scored) — tablet 🇺🇸 USA FDA Primidone · How Supplied
- 50 mg tablet (scored) — tablet 🇺🇸 USA FDA Primidone · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Primidone · Pregnancy
“To provide information regarding the effects of in utero exposure to primidone, physicians are advised to recommend that pregnant patients taking primidone enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Primidone · Nursing Mothers
“There is evidence in mothers treated with primidone, the drug appears in the milk in substantial quantities.”
- 👶 ChildrenNo data
The source for this drug has no section for this group.
- 👴 Older adultsNo data
The source for this drug has no section for this group.
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA040586
- DailyMed (FDA label)FDA Primidone
- MedlinePlus (NIH)Primidone
- WHO ATC/DDDN03AA03
- Darooyab (Iran)Primidone
🇮🇷 Registered in Iran Darooyab · G-681/Primidone
Dosage forms with Iranian generic codes, per Darooyab.
- 01650 · PRIMIDONE 125MG/5ML 250ML SUSP · سوسپانسیون پریمیدون ۱۲۵ میلیگرم / ۵ میلیلیتر ۲۵۰ میلیلیتر
- 01051 · PRIMIDONE 250MG TAB · قرص پریمیدون ۲۵۰ میلیگرم
- 01052 · PRIMIDONE 250MG/5ML SUSP · سوسپانسیون پریمیدون ۲۵۰ میلیگرم / ۵ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Primidone · How SuppliedFDA Primidone · Dosage and AdministrationFDA Primidone · ContraindicationsFDA Primidone · WarningsFDA Primidone · SPL approval / marketing categoryFDA Primidone · PregnancyFDA Primidone · Nursing Mothers
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-681/Primidone
- Clinical review⚠ Unverified