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Divalproex sodium (valproate)
والپروات (دیوالپروکس)
🧠 PsychiatryAnticonvulsant and mood stabilizer
Market / country: 🇺🇸 USA
Depakote (US)
🧮 Dose calculator
Epilepsy (complex partial / absence seizures) · Regimen source: FDA Divalproex · 2.2
- • Increase 5–10 mg/kg/week; response usually below 60 mg/kg/day; serum 50–100 mcg/mL. Daily doses above 250 mg in divided doses. FDA Divalproex · 2.2
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🛡️ Safety & information
Contraindications
- ⛔ Hepatic disease or significant dysfunction; POLG mitochondrial disorders; hypersensitivity. FDA Divalproex · 4
- ⚠️ Under 2 years: considerably increased risk of fatal hepatotoxicity; extreme caution, sole agent. FDA Divalproex · 8.4
Warnings
- • Boxed warning: fatal hepatotoxicity, teratogenicity and pancreatitis. FDA Divalproex · WARNING: LIFE THREATENING ADVERSE REACTIONS
Monitoring
- • Liver tests before and frequently during therapy, especially first 6 months. FDA Divalproex · WARNING: LIFE THREATENING ADVERSE REACTIONS
Formulations
- 125 mg delayed-release tablet — tablet 🇺🇸 USA FDA Divalproex · 3
- 250 mg delayed-release tablet — tablet 🇺🇸 USA FDA Divalproex · 3
- 500 mg delayed-release tablet — tablet 🇺🇸 USA FDA Divalproex · 3
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Divalproex · 3FDA Divalproex · 2.2FDA Divalproex · 2.1FDA Divalproex · 2.3FDA Divalproex · 4FDA Divalproex · 8.4FDA Divalproex · WARNING: LIFE THREATENING ADVERSE REACTIONS
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Clinical review⚠ Unverified