Brivaracetam
بریواستام
🧠 Nervous SystemAntiepileptic (SV2A ligand)
Market / country: 🇺🇸 USA
Briviact (US)
🧮 Dose calculator
Epilepsy (complex partial / absence seizures) · Regimen source: FDA Briviact · 2.1, Table 1
- • No titration needed; withdraw gradually. Up to double the dose with rifampin. FDA Briviact · 2.1FDA Briviact · 2.4FDA Briviact · 2.6
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to brivaracetam or excipients (bronchospasm and angioedema reported). FDA Briviact · 4
Warnings
- • Suicidal ideation; somnolence and fatigue; psychiatric reactions (irritability, depression, psychosis). FDA Briviact · 5
Formulations
- 10 mg tablet — tablet 🇺🇸 USA FDA Briviact · 3
- 25 mg tablet — tablet 🇺🇸 USA FDA Briviact · 3
- 50 mg tablet — tablet 🇺🇸 USA FDA Briviact · 3
- 75 mg tablet — tablet 🇺🇸 USA FDA Briviact · 3
- 100 mg tablet — tablet 🇺🇸 USA FDA Briviact · 3
- 10 mg/mL oral solution — solution 🇺🇸 USA FDA Briviact · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Briviact · 8.1
“Risk Summary Available data from the North American Antiepileptic Drug (NAAED) pregnancy registry, a prospective cohort study, case reports, and a case series are insufficient to identify a risk of major birth defects, miscarriage or other maternal or fetal outcomes associated with BRIVIACT use during pregnancy.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Briviact · 8.2
“Risk Summary Data from published literature indicate that brivaracetam is present in human milk.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Briviact · 8.4
“Safety and effectiveness of BRIVIACT have been established in pediatric patients 1 month to less than 16 years of age.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Briviact · 8.5
“In general, dose selection for an elderly patient should be judicious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy [see Clinical Pharmacology (12.3) ] .”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA205836
- DailyMed (FDA label)FDA Briviact
- MedlinePlus (NIH)BrivaracetamBrivaracetam Injection
- WHO ATC/DDDN03AX23
- Darooyab (Iran)Brivaracetam
🇮🇷 Registered in Iran Darooyab · G-4145/Brivaracetam
Dosage forms with Iranian generic codes, per Darooyab.
- 53459 · BRIVARACETAM 100 mg TABLET · قرص بریواراستام ۱۰۰ میلیگرم
- 53461 · BRIVARACETAM 75 mg TABLET · قرص بریواراستام ۷۵ میلیگرم
- 53462 · BRIVARACETAM 50 mg TABLET · قرص بریواراستام ۵۰ میلیگرم
- 53460 · BRIVARACETAM 25 mg TABLET · قرص بریواراستام ۲۵ میلیگرم
- 53463 · BRIVARACETAM 10 mg TABLET · قرص بریواراستام ۱۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Briviact · 3FDA Briviact · 2.1, Table 1FDA Briviact · 2.1FDA Briviact · 2.4FDA Briviact · 2.6FDA Briviact · 4FDA Briviact · 5FDA Briviact · 8.1FDA Briviact · 8.2FDA Briviact · 8.4FDA Briviact · 8.5FDA Briviact · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-4145/Brivaracetam
- Clinical review⚠ Unverified