Doz

Gemcitabine

جمسیتابین

⚠ Unverified

🎗️ Antineoplastic And Immunomodulating AgentsNucleoside antimetabolite

🤰 Pregnancy:Dangerous / avoid🤱 Breastfeeding:Dangerous / avoid👶 Children:Use with caution👴 Older adults:No specific problem stated⚥ Females & males of reproductive potential:Use with caution 🇮🇷 Registered in Iran⛔ 1 contraindications 🇺🇸 FDA approved generic (ANDA) ANDA202485ATC L01BC05

Market / country: 🇺🇸 USA

Gemzar (US)

🧮 Dose calculator

Pancreatic cancer · Regimen source: FDA Gemcitabine · 2.4

  • • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Gemcitabine · 2

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🛡️ Safety & information

Contraindications

Warnings

  • • Schedule-dependent toxicity (infusion >60 min or more than weekly is more toxic); myelosuppression; severe skin reactions; pulmonary toxicity; HUS; hepatotoxicity; capillary leak; PRES. FDA Gemcitabine · 5

Formulations

👥 Special populations

  • 🤰 PregnancyDangerous / avoid

    Label: can cause fetal harm. Dangerous in pregnancy. FDA Gemcitabine · 8.1

    “Risk Summary Based on animal data and its mechanism of action, Gemcitabine for Injection can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .”
  • 🤱 BreastfeedingDangerous / avoid

    Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Gemcitabine · 8.2

    “Due to the potential for serious adverse reactions in breastfed infants from Gemcitabine for Injection, advise women not to breastfeed during treatment with Gemcitabine for Injection and for at least one week following the last dose.”
  • 👶 ChildrenUse with caution

    The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Gemcitabine · 8.4

    “The safety and effectiveness of Gemcitabine for Injection have not been established in pediatric patients.”
  • 👴 Older adultsNo specific problem stated

    Label: no specific difference or dose adjustment stated for older adults. FDA Gemcitabine · 8.5

    “In clinical studies which enrolled 979 patients with various malignancies who received single agent Gemcitabine for Injection, no overall differences in safety were observed between patients aged 65 and older and younger patients, with the exception of a higher rate of Grade 3 or 4 thrombocytopenia in older patients …”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Gemcitabine · 8.3

    “Contraception Gemcitabine for Injection can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations ( 8.1 )].”

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