Dexrazoxane

دکس‌رازوکسان

⚠ Unverified

🧪 VariousAnthracycline cardioprotectant

Market / country: 🇺🇸 USA

Zinecard (US)

🧮 Dose calculator

Breast cancer (hormonal therapy) · Regimen source: FDA Dexrazoxane · 2.1FDA Dexrazoxane · 2.2

⛔ Dose = 10 × the doxorubicin dose (mg/m²); slow push or rapid drip; give doxorubicin within 30 min after it ends (never before). CrCl <40: 5:1 ratio. FDA Dexrazoxane · 2.1FDA Dexrazoxane · 2.2

🛡️ Safety & information

Contraindications

Warnings

  • • Added myelosuppression; cardiac toxicity still possible; secondary malignancy; embryo-fetal toxicity. FDA Dexrazoxane · 5

Formulations

👥 Special populations

  • 🤰 PregnancyDangerous / avoid

    Label: can cause fetal harm. Dangerous in pregnancy. FDA Dexrazoxane · 8.1

    “Risk Summary Dexrazoxane can cause fetal harm when administered to pregnant women.”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Dexrazoxane · 8.3

    “Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from dexrazoxane, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.”
  • 👶 ChildrenSafety not established

    Label: safety and effectiveness in children have not been established. FDA Dexrazoxane · 8.4

    “The safety and effectiveness of dexrazoxane in pediatric patients have not been established [see Warnings and Precautions (5.4) ] .”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Dexrazoxane · 8.5

    “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”
  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

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