Letrozole

🧮 Dose calculator

Breast cancer (hormonal therapy) · Regimen source: FDA Letrozole · 2.1

• • Cirrhosis or severe hepatic impairment: 2.5 mg every other day. Use for infertility is not in the FDA label. FDA Letrozole · 2.5

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyContraindicated

  Label: contraindicated in pregnancy. FDA Letrozole · 4

  “Pregnancy: Letrozole can cause fetal harm [see Use in Specific Populations (8.1) ] .”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Letrozole · 8.2

  “Because of the potential for serious adverse reactions in breastfed infants from letrozole, advise lactating women not to breastfeed while taking letrozole and for at least 3 weeks after the last dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Letrozole · 8.4

  “The safety and effectiveness in pediatric patients have not been established.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Letrozole · 8.5

  “However, in comparison to tamoxifen, no overall differences with regards to the safety and efficacy profiles were observed between elderly patients and younger patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Letrozole · 8.3

  “Contraception Females Based on animal studies, letrozole tablets can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1) ] .”