Doz

Methotrexate (oral)

متوترکسات (خوراکی)

⚠ Unverified

🎗️ Antineoplastic And Immunomodulating AgentsAntimetabolite / DMARD

🤰 Pregnancy:Contraindicated🤱 Breastfeeding:Use with caution👶 Children:Use with caution👴 Older adults:Use with caution⚥ Females & males of reproductive potential:Use with caution 🇮🇷 Registered in Iran⛔ 1 contraindications 🇺🇸 FDA approved generic (ANDA) ANDA217552ATC L04AX03

Market / country: 🇺🇸 USA

Trexall (US)

🧮 Dose calculator

Rheumatoid arthritis · Regimen source: FDA Methotrexate tab · 2.3FDA Methotrexate tab · 2.1

⛔ ONCE WEEKLY — not daily. Daily dosing by mistake has caused deaths. Start 7.5 mg orally once weekly, escalate to response; above 20 mg weekly increases serious toxicity (myelosuppression). FDA Methotrexate tab · 2.3FDA Methotrexate tab · 2.1

🛡️ Safety & information

Contraindications

Warnings

  • • Boxed warning: embryo-fetal toxicity, hypersensitivity, serious adverse reactions (marrow, liver, lung, kidney) and medication errors; verify pregnancy status before starting. FDA Methotrexate tab · Boxed Warning

Formulations

👥 Special populations

  • 🤰 PregnancyContraindicated

    Label: contraindicated in pregnancy. FDA Methotrexate tab · 4

    “Methotrexate tablets are contraindicated in: • Pregnant women receiving methotrexate tablets for treatment of non-neoplastic diseases [see Warnings and Precautions (5.1), and Use in Specific Populations (8.1, 8.3)]. • Patients with a history of severe hypersensitivity reactions, including anaphylaxis, to methotrexate.”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Methotrexate tab · 8.2

    “Risk Summary Limited published literature report the presence of methotrexate in human milk in low amounts, with the highest breast milk to plasma concentration ratio reported to be 0.08:1.”
  • 👶 ChildrenUse with caution

    The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Methotrexate tab · 8.4

    “The safety and effectiveness of methotrexate in pediatric patients have been established for the treatment of ALL as part of the combination chemotherapy maintenance regimen and the treatment of pJIA [see Indications and Usage (1), Dosage and Administration (2)] .”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Methotrexate tab · 8.5

    “Clinical studies of methotrexate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Methotrexate tab · 8.3

    “Contraception Females Advise females of reproductive potential to use effective contraception during treatment with methotrexate and for 6 months after the final dose.”

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