Pemetrexed

🧮 Dose calculator

Lung cancer (small-cell and non-small-cell) · Regimen source: FDA Alimta · 2.1

• • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Alimta · 2.1
• • Premedication: folic acid 400–1000 mcg daily from 7 days before, vitamin B12 IM every 9 weeks, dexamethasone 4 mg twice daily the day before, of and after. FDA Alimta · 2.4

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Alimta · 8.1

  “Risk Summary Based on findings from animal studies and its mechanism of action, ALIMTA can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Alimta · 8.2

  “Because of the potential for serious adverse reactions in breastfed infants from ALIMTA, advise women not to breastfeed during treatment with ALIMTA and for one week after the last dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Alimta · 8.4

  “The safety and effectiveness of ALIMTA in pediatric patients have not been established.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Alimta · 8.5

  “No overall differences in effectiveness were observed between these patients and younger patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Alimta · 8.3

  “Contraception Females Because of the potential for genotoxicity, advise females of reproductive potential to use effective contraception during treatment with ALIMTA and for 6 months after the last dose.”