Bevacizumab

🧮 Dose calculator

Colorectal cancer · Regimen source: FDA Avastin · 2.2

• • With FOLFOX4: 10 mg/kg every 2 weeks; or 7.5 mg/kg every 3 weeks second-line. Not within 28 days before or after major surgery. FDA Avastin · 2.2FDA Avastin · 2.1
• • Only under an oncologist; protocol, cycle interval and adjustment rest with the treating team. FDA Avastin · 2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Avastin · 8.1

  “Risk Summary Based on findings from animal studies and its mechanism of action [see Clinical Pharmacology (12.1) ], Avastin may cause fetal harm in pregnant women.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Avastin · 8.2

  “Because of the potential for serious adverse reactions in breastfed infants, advise women not to breastfeed during treatment with Avastin and for 6 months after the last dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Avastin · 8.4

  “The safety and effectiveness of Avastin in pediatric patients have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Avastin · 8.5

  “… ATE was greater in patients ≥ 65 years (8% vs. 3%) as compared to patients < 65 years (2% vs. 1%) [see Warnings and Precautions (5.4) ].”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Avastin · 8.3

  “Contraception Females Avastin may cause fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1) ] .”