Docetaxel

🧮 Dose calculator

Breast cancer (hormonal therapy) · Regimen source: FDA Docetaxel · 2.1

• • Calculator gives the lower bound. Adjuvant (TAC): 75 mg/m² 1 h after doxorubicin 50 and cyclophosphamide 500. Premedicate dexamethasone 8 mg twice daily for 3 days starting the day before. FDA Docetaxel · 2.1FDA Docetaxel · 2.6
• • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Docetaxel · 2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Docetaxel · 8.1

  “Risk Summary Based on findings in animal reproduction studies and its mechanism of action, docetaxel injection can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology (12.1) ] .”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Docetaxel · 8.2

  “Because of the potential for serious adverse reactions in a breastfed child, advise women not to breastfeed during treatment with docetaxel injection and for 1 week after the last dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Docetaxel · 8.4

  “The efficacy of docetaxel injection in pediatric patients as monotherapy or in combination has not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Docetaxel · 8.5

  “In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy in elderly patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Docetaxel · 8.3

  “Contraception Females Based on genetic toxicity findings, advise females of reproductive potential to use effective contraception during treatment and for 2 months after the last dose of docetaxel injection.”