Leuprolide

لوپرولید

⚠ Unverified

🎗️ Antineoplastic And Immunomodulating AgentsGnRH agonist

Market / country: 🇺🇸 USA

Lupron Depot (US)

🧮 Dose calculator

Prostate cancer · Regimen source: FDA Lupron Depot · 2.1

  • • Healthcare provider only; no fractional doses or combinations of depot products (different release). FDA Lupron Depot · 2.1

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🛡️ Safety & information

Contraindications

Warnings

  • • Transient testosterone surge and tumour flare (bone pain, spinal cord compression, urinary obstruction) in the first weeks; metabolic syndrome and diabetes; cardiovascular disease; QT prolongation; convulsions. FDA Lupron Depot · 5

Formulations

👥 Special populations

  • 🤰 PregnancyDangerous / avoid

    Label: can cause fetal harm. Dangerous in pregnancy. FDA Lupron Depot · 8.1

    “Risk Summary Based on findings in animal studies and mechanism of action, LUPRON DEPOT may cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Lupron Depot · 8.2

    “The safety and efficacy of LUPRON DEPOT have not been established in females.”
  • 👶 ChildrenUse with caution

    The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Lupron Depot · 8.4

    “See LUPRON DEPOT-PED ® (leuprolide acetate for depot suspension) labeling for the safety and effectiveness in children with central precocious puberty.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Lupron Depot · 8.5

    “In the clinical trials for LUPRON DEPOT in prostate cancer 80% of the subjects studied were at least 65 years of age.”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Lupron Depot · 8.3

    “Infertility Males Based on findings in animals and mechanism of action, LUPRON DEPOT may impair fertility in males of reproductive potential [see Nonclinical Toxicology ( 13.1 )] .”

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