Leuprolide
لوپرولید
🎗️ Antineoplastic And Immunomodulating AgentsGnRH agonist
Market / country: 🇺🇸 USA
Lupron Depot (US)
🧮 Dose calculator
Prostate cancer · Regimen source: FDA Lupron Depot · 2.1
- • Healthcare provider only; no fractional doses or combinations of depot products (different release). FDA Lupron Depot · 2.1
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to GnRH, GnRH agonists or any excipient. FDA Lupron Depot · 4
Warnings
- • Transient testosterone surge and tumour flare (bone pain, spinal cord compression, urinary obstruction) in the first weeks; metabolic syndrome and diabetes; cardiovascular disease; QT prolongation; convulsions. FDA Lupron Depot · 5
Formulations
- 7.5 mg depot kit (1-month) — powder for injection 🇺🇸 USA FDA Lupron Depot · 3
- 22.5 mg depot kit (3-month) — powder for injection 🇺🇸 USA FDA Lupron Depot · 3
- 30 mg depot kit (4-month) — powder for injection 🇺🇸 USA FDA Lupron Depot · 3
- 45 mg depot kit (6-month) — powder for injection 🇺🇸 USA FDA Lupron Depot · 3
👥 Special populations
- 🤰 PregnancyDangerous / avoid
Label: can cause fetal harm. Dangerous in pregnancy. FDA Lupron Depot · 8.1
“Risk Summary Based on findings in animal studies and mechanism of action, LUPRON DEPOT may cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Lupron Depot · 8.2
“The safety and efficacy of LUPRON DEPOT have not been established in females.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Lupron Depot · 8.4
“See LUPRON DEPOT-PED ® (leuprolide acetate for depot suspension) labeling for the safety and effectiveness in children with central precocious puberty.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Lupron Depot · 8.5
“In the clinical trials for LUPRON DEPOT in prostate cancer 80% of the subjects studied were at least 65 years of age.”
- ⚥ Females & males of reproductive potentialUse with caution
Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Lupron Depot · 8.3
“Infertility Males Based on findings in animals and mechanism of action, LUPRON DEPOT may impair fertility in males of reproductive potential [see Nonclinical Toxicology ( 13.1 )] .”
🔗 Reference links
- FDA (approval record)NDA020517
- DailyMed (FDA label)FDA Lupron Depot
- MedlinePlus (NIH)Leuprolide Injection
- WHO ATC/DDDL02AE02
- Darooyab (Iran)Leuprorelin
🇮🇷 Registered in Iran Darooyab · G-2704/Leuprorelin
Dosage forms with Iranian generic codes, per Darooyab.
- 16637 · LEUPROLIDE 7.5MG AMP · آمپول لوپرولاید ۷٫۵ میلیگرم
- 18097 · LEUPRORELIN ACETATE 2.8 MG VIAL · ویال لوپرورلین استات ۲٫۸ میلیگرم
- 18438 · LEUPRORELIN ACETATE 3.75MG SYRINGE · سرنگ لوپرورلین استات ۳٫۷۵ میلیگرم
- 01570 · LEUPRORELIN ACETATE 3.75MG VIAL · ویال لوپرورلین استات ۳٫۷۵ میلیگرم
- 17435 · LEUPRORELIN ACETATE 7.5MG INJ · فرآورده تزریقی لوپرورلین استات ۷٫۵ میلیگرم
- 00000 · LEUPRORELIN ACETATE 22.5MG VIAL · ویال لوپرورلین استات ۲۲٫۵ میلیگرم
- 22422 · LEUPRORELIN ACETATE INJECTION, POWDER, FOR SUSPENSION, EXTENDED RELEASE PARENTERAL 7.5 mg · پودر تزریقی لوپرورلین استات ۷٫۵ میلیگرم
- 50346 · LEUPRORELIN ACETATE INJECTION, POWDER, FOR SUSPENSION, EXTENDED RELEASE PARENTERAL 22.5 mg · پودر تزریقی لوپرورلین استات ۲۲٫۵ میلیگرم
- 50541 · LEUPRORELIN ACETATE INJECTION, POWDER, FOR SUSPENSION, EXTENDED RELEASE PARENTERAL 45 mg · پودر تزریقی لوپرورلین استات ۴۵ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Lupron Depot · 3FDA Lupron Depot · 2.1FDA Lupron Depot · 2.2FDA Lupron Depot · 2.3FDA Lupron Depot · 2.4FDA Lupron Depot · 4FDA Lupron Depot · 5FDA Lupron Depot · 8.1FDA Lupron Depot · 8.2FDA Lupron Depot · 8.4FDA Lupron Depot · 8.5FDA Lupron Depot · 8.3FDA Lupron Depot · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-2704/Leuprorelin
- Clinical review⚠ Unverified