Vinorelbine

🧮 Dose calculator

Lung cancer (small-cell and non-small-cell) · Regimen source: FDA Vinorelbine · 2.1

• • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Vinorelbine · 2.1
• • Reduce or withhold for low neutrophils or raised bilirubin per 2.2 tables. IV only. FDA Vinorelbine · 2.2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Vinorelbine · 8.1

  “Risk Summary Based on findings from animal studies and its mechanism of action [see Clinical Pharmacology ( 12.1 )] , vinorelbine can cause fetal harm when administered to a pregnant woman.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Vinorelbine · 8.2

  “Because of the potential for serious adverse reactions in breastfed infants from vinorelbine, advise women not to breastfeed during treatment with vinorelbine and for 9 days after the final dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Vinorelbine · 8.4

  “The safety and effectiveness of vinorelbine in pediatric patients have not been established.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Vinorelbine · 8.5

  “No overall differences in safety, efficacy and pharmacokinetic parameters were observed between these patients and younger patients [see Clinical Pharmacology ( 12.3 )] .”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Vinorelbine · 8.3

  “Contraception Females Vinorelbine can cause fetal harm when administered to pregnant women [see Use in Specific Populations ( 8.1 )] .”