Lung cancer (small-cell and non-small-cell)

NSCLC, SCLC and other indications — 1200 mg IV every 3 weeks (or 840 mg every 2 weeks or 1680 mg every 4 weeks)

First-line non-squamous NSCLC — 15 mg/kg every 3 weeks with carboplatin and paclitaxel

NSCLC after platinum failure — 75 mg/m² over 1 h every 3 weeks

NSCLC, SCLC, biliary tract, liver and other cancers — weight ≥30 kg: 1500 mg IV every 3 or 4 weeks by regimen

Weight under 30 kg — 20 mg/kg IV every 3 or 4 weeks

Metastatic EGFR-mutated NSCLC — 150 mg on an empty stomach once daily

Small-cell lung cancer (combination) — 35 mg/m²/day for 4 days to 50 mg/m²/day for 5 days

First-line metastatic NSCLC with exon 19 deletion or L858R — 250 mg once daily

NSCLC — 1000 mg/m² on days 1, 8 and 15 every 28 days (or 1250 mg/m² days 1 and 8 every 21 days)

Single agent (NSCLC, melanoma, RCC, Hodgkin and others) — 240 mg every 2 weeks or 480 mg every 4 weeks (≥40 kg)

EGFR-mutated NSCLC (exon 19 deletion or L858R) — 80 mg once daily

Adults (melanoma, NSCLC, head & neck, urothelial and other indications) — 200 mg every 3 weeks or 400 mg every 6 weeks

Non-squamous NSCLC — 500 mg/m² IV over 10 min on day 1 every 21 days

Non-small-cell lung cancer — 30 mg/m² IV once weekly (single agent, or 25–30 with cisplatin)