Vincristine
وینکریستین
🎗️ Antineoplastic And Immunomodulating AgentsVinca alkaloid
Market / country: 🇺🇸 USA
Oncovin (US)
🧮 Dose calculator
Acute lymphoblastic leukaemia (ALL) · Regimen source: FDA Vincristine · Dosage and Administration
- • IV only — intrathecal injection is fatal. Direct bilirubin >3 mg/dL: 50% dose. Calculate with extreme care (overdose can be fatal). FDA Vincristine · Dosage and AdministrationFDA Vincristine · Warnings
- • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Vincristine · Dosage and Administration
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Demyelinating form of Charcot–Marie–Tooth syndrome. FDA Vincristine · Contraindications
Warnings
- • Boxed warning: IV only — fatal if given intrathecally; extravasation causes severe irritation. Dose-related neurotoxicity. FDA Vincristine · Warnings
Formulations
- 1 mg/mL (1 mg, 2 mg vials) — injection 🇺🇸 USA FDA Vincristine · How Supplied
👥 Special populations
- 🤰 PregnancyDangerous / avoid
Label: can cause fetal harm. Dangerous in pregnancy. FDA Vincristine · Pregnancy
“Vincristine sulfate can cause fetal harm when administered to a pregnant woman.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Vincristine · Nursing Mothers
“Because many drugs are excreted in human milk and because of the potential for serious adverse reactions due to vincristine sulfate in nursing infants, a decision should be made either to discontinue nursing or the drug, taking into account the importance of the drug to the mother.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Vincristine · Pediatric Use
“See DOSAGE AND ADMINISTRATION section.”
- 👴 Older adultsNo data
The source for this drug has no section for this group.
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA071484
- DailyMed (FDA label)FDA Vincristine
- MedlinePlus (NIH)Vincristine Injection
- WHO ATC/DDDL01CA02
- Darooyab (Iran)Vincristine
🇮🇷 Registered in Iran Darooyab · G-1091/Vincristine
Dosage forms with Iranian generic codes, per Darooyab.
- 01284 · VINCRISTINE SULFATE 1MG VIAL · ویال وینکریستین سولفات ۱ میلیگرم
- 02194 · VINCRISTINE SULFATE 1MG/ML AMP · آمپول وینکریستین سولفات ۱ میلیگرم / میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Vincristine · How SuppliedFDA Vincristine · Dosage and AdministrationFDA Vincristine · WarningsFDA Vincristine · ContraindicationsFDA Vincristine · SPL approval / marketing categoryFDA Vincristine · PregnancyFDA Vincristine · Nursing MothersFDA Vincristine · Pediatric Use
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-1091/Vincristine
- Clinical review⚠ Unverified