Rituximab

🧮 Dose calculator

B-cell non-Hodgkin lymphoma and CLL · Regimen source: FDA Rituxan · 2.2

• • Premedicate before each infusion: acetaminophen and an antihistamine (and steroid per regimen). IV infusion only, never push or bolus. FDA Rituxan · 2.8FDA Rituxan · 2.1
• • Relapsed/refractory: weekly for 4 or 8 doses; untreated: day 1 of each chemo cycle up to 8 doses. CLL: cycle 1 → 375, cycles 2–6 → 500 mg/m². FDA Rituxan · 2.2FDA Rituxan · 2.3

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Rituxan · 8.1

  “Risk Summary Based on human data, RITUXAN can cause adverse developmental outcomes including B-cell lymphocytopenia in infants exposed to RITUXAN in-utero ( see Clinical Considerations ).”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Rituxan · 8.2

  “Given that the clinical significance of this finding for children is not known, advise women not to breastfeed during treatment with RITUXAN and for 6 months after the last dose due to the potential of serious adverse reactions in breastfed children.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Rituxan · 8.4

  “Mature B-Cell NHL/B-AL The safety and effectiveness of RITUXAN in combination with chemotherapy for the treatment of previously untreated, advanced stage, CD20-positive DLBCL/BL/BLL/B-AL have been established in pediatric patients aged 6 months and older.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Rituxan · 8.5

  “Patients 70 years or older received lower dose intensity of fludarabine and cyclophosphamide compared to younger patients, regardless of the addition of RITUXAN.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Rituxan · 8.3

  “Contraception Females Advise females of reproductive potential to use effective contraception during treatment with RITUXAN and for 12 months after the last dose.”