Azathioprine
آزاتیوپرین
🎗️ Antineoplastic And Immunomodulating AgentsImmunosuppressant (antimetabolite)
Market / country: 🇺🇸 USA
Imuran (US)
🧮 Dose calculator
Rheumatoid arthritis · Regimen source: FDA Azathioprine · Dosage and Administration — Rheumatoid Arthritis
- • Single or twice-daily. From week 6–8 increase 0.5 mg/kg every 4 weeks up to 2.5 mg/kg. Test TPMT and NUDT15 before starting (deficiency → major dose reduction). FDA Azathioprine · Dosage and Administration — Rheumatoid ArthritisFDA Azathioprine · Dosage and Administration
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity; rheumatoid arthritis in pregnancy; RA previously treated with alkylating agents (malignancy risk). FDA Azathioprine · Contraindications
Warnings
- • Boxed warning: malignancy (lymphoma and skin cancer) with chronic immunosuppression. FDA Azathioprine · Boxed Warning
Important interactions
- • Allopurinol and febuxostat: markedly increased toxicity (febuxostat contraindicated). FDA Azathioprine · Drug Interactions
Formulations
- 50 mg tablet (scored) — tablet 🇺🇸 USA FDA Azathioprine · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Azathioprine · Precautions/Warnings – Pregnancy
“Teratogenic Effects : See WARNINGS section.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Azathioprine · Precautions/Warnings – Nursing Mothers
“The use of Azathioprine Tablets in nursing mothers is not recommended.”
- 👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Azathioprine · Precautions/Warnings – Pediatric Use
“Safety and efficacy of azathioprine in pediatric patients have not been established.”
- 👴 Older adultsNo data
The source for this drug has no section for this group.
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA075252
- DailyMed (FDA label)FDA Azathioprine
- MedlinePlus (NIH)Azathioprine
- WHO ATC/DDDL04AX01
- Darooyab (Iran)Azathioprine
🇮🇷 Registered in Iran Darooyab · G-2730/Azathioprine
Dosage forms with Iranian generic codes, per Darooyab.
- 20225 · AZATHIOPRINE 100MG TAB · قرص آزاتیوپرین ۱۰۰ میلیگرم
- 17665 · AZATHIOPRINE 25MG TAB · قرص آزاتیوپرین ۲۵ میلیگرم
- 00122 · AZATHIOPRINE 50MG TAB · قرص آزاتیوپرین ۵۰ میلیگرم
- 01399 · AZATHIOPRINE SODIUM 50MG AMP · آمپول آزاتیوپرین سدیم ۵۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Azathioprine · How SuppliedFDA Azathioprine · Dosage and Administration — Rheumatoid ArthritisFDA Azathioprine · Dosage and AdministrationFDA Azathioprine · ContraindicationsFDA Azathioprine · Boxed WarningFDA Azathioprine · Drug InteractionsFDA Azathioprine · SPL approval / marketing categoryFDA Azathioprine · Precautions/Warnings – PregnancyFDA Azathioprine · Precautions/Warnings – Nursing MothersFDA Azathioprine · Precautions/Warnings – Pediatric Use
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-2730/Azathioprine
- Clinical review⚠ Unverified