Leflunomide

لفلونوماید

⚠ Unverified

🎗️ Antineoplastic And Immunomodulating AgentsDMARD (pyrimidine synthesis inhibitor)

Market / country: 🇺🇸 USA

Arava (US)

🧮 Dose calculator

Rheumatoid arthritis · Regimen source: FDA Leflunomide · 2.1

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🛡️ Safety & information

Contraindications

  • ⛔ Pregnancy; severe hepatic impairment; hypersensitivity; concomitant teriflunomide. FDA Leflunomide · 4

Warnings

Formulations

👥 Special populations

  • 🤰 PregnancyContraindicated

    Label: contraindicated in pregnancy. FDA Leflunomide · 4

    “Leflunomide is contraindicated in: Pregnant women.”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Leflunomide · 8.2

    “Risk Summary Clinical lactation studies have not been conducted to assess the presence of leflunomide in human milk, the effects of leflunomide on the breastfed child, or the effects of leflunomide on milk production.”
  • 👶 ChildrenSafety not established

    Label: safety and effectiveness in children have not been established. FDA Leflunomide · 8.4

    “The safety and effectiveness of leflunomide in pediatric patients have not been established.”
  • 👴 Older adultsNo specific problem stated

    Label: no specific difference or dose adjustment stated for older adults. FDA Leflunomide · 8.5

    “No dosage adjustment is needed in patients over 65.”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Leflunomide · 8.3

    “Contraception Females Females of reproductive potential should use effective contraception while taking leflunomide.”

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