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Anakinra

آناکینرا

⚠ Unverified

🎗️ Antineoplastic And Immunomodulating AgentsIL-1 receptor antagonist

🤰 Pregnancy:Use with caution 🤱 Breastfeeding:Use with caution 👶 Children:Use with caution 👴 Older adults:Use with caution 🇮🇷 Registered in Iran ⛔ 1 contraindications 🇺🇸 FDA approved (BLA) BLA103950 ATC L04AC03

Market / country: 🇺🇸 USA

Kineret (US)

🧮 Dose calculator

Disease / regimen

Rheumatoid arthritis · Regimen source: FDA Kineret · 2.1

Formulation

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🛡️ Safety & information

Contraindications

⛔ Hypersensitivity to E. coli-derived proteins or anakinra. FDA Kineret · 4

Warnings

• Serious infections; not with TNF blockers; hypersensitivity; neutropenia (ANC baseline, monthly for 3 months, then quarterly); no live vaccines. FDA Kineret · 5

Renal adjustment

• eGFR < 30: CrCl <30 or ESRD: same dose every other day. FDA Kineret · 2.4

Formulations

100 mg/0.67 mL graduated prefilled syringe (20–100 mg) — injection 🇺🇸 USA FDA Kineret · 3

👥 Special populations

🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Kineret · 8.1
“Risk Summary Available data from retrospective studies and case reports on KINERET use in pregnant women are insufficient to identify a drug associated risk of major birth defects, miscarriage, or maternal and fetal adverse events.”
🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Kineret · 8.2
“Risk Summary There are no data on the presence of anakinra in either human or animal milk or the effects on milk production.”
👶 ChildrenUse with caution
Label: used in paediatric NOMID (including under 2 y) at 1–2 mg/kg/day; not established for JRA. FDA Kineret · 8.4
“The NOMID study included 36 pediatric patients: 13 below 2 years, 18 between 2 and 11 years, and 5 between 12 and 17 years of age.”
👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Kineret · 8.5
“Because there is a higher incidence of infections in the elderly population in general, caution should be used in treating the elderly.”
⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.

🔗 Reference links

FDA (approval record)BLA103950
DailyMed (FDA label)FDA Kineret
MedlinePlus (NIH)Anakinra
WHO ATC/DDDL04AC03
Darooyab (Iran)Anakinra

🇮🇷 Registered in Iran Darooyab · G-16/Anakinra

Dosage forms with Iranian generic codes, per Darooyab.

18006 · ANAKINRA 100 MG SYRING · سرنگ آناکینرا ۱۰۰ میلی‌گرم

📚 Reference status for this drug

Shows which sources have references recorded for this drug and which do not.

FDA label (DailyMed)✅ Present
FDA Kineret · 3 FDA Kineret · 2.1 FDA Kineret · 2.2 FDA Kineret · 2.3 FDA Kineret · 4 FDA Kineret · 5 FDA Kineret · 2.4 FDA Kineret · SPL approval / marketing category FDA Kineret · 8.1 FDA Kineret · 8.2 FDA Kineret · 8.4 FDA Kineret · 8.5
UK SmPC (eMC / MHRA)❌ Not present
Published guideline❌ Not present
Licensed reference (medical school)❌ Not present
Iranian leaflet (IFDA)❌ Not present
Pharmacy website (secondary, unreliable)✅ Present
Darooyab · G-16/Anakinra
Clinical review⚠ Unverified