Oxaliplatin

🧮 Dose calculator

Colorectal cancer · Regimen source: FDA Oxaliplatin · 2.1

• • Concurrently with leucovorin 200 mg/m² (separate bag), then fluorouracil. Adjuvant up to 12 cycles. Prolong to 6 h for acute infusion reactions. FDA Oxaliplatin · 2.1FDA Oxaliplatin · 2.2
• • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Oxaliplatin · 2.1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Oxaliplatin · 8.1

  “Risk Summary Based on its direct interaction with DNA, oxaliplatin can cause fetal harm when administered to a pregnant woman.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Oxaliplatin · 8.2

  “Because of the potential for serious adverse reactions in breastfed infants, advise women not to breastfeed during treatment with oxaliplatin and for 3 months after the final dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Oxaliplatin · 8.4

  “The safety and effectiveness of oxaliplatin in pediatrics have not been established.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Oxaliplatin · 8.5

  “No overall differences in effectiveness were observed between these patients and younger adults.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Oxaliplatin · 8.3

  “Contraception Oxaliplatin can cause embryo-fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1) ] .”