Irinotecan

🧮 Dose calculator

Colorectal cancer · Regimen source: FDA Irinotecan · 2.1, Table 1

• • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Irinotecan · 2.1
• • Single-agent weekly is also 125 mg/m² (days 1, 8, 15, 22 every 6 weeks). UGT1A1*28 homozygous: reduce by one dose level. FDA Irinotecan · 2.2, Table 3FDA Irinotecan · 2.3

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Irinotecan · 8.1

  “Risk Summary Based on findings from animal studies and its mechanism of action, Irinotecan Hydrochloride Injection can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Irinotecan · 8.2

  “Because of the potential for serious adverse reactions from Irinotecan Hydrochloride Injection in the breastfed child, advise lactating women not to breastfeed during treatment with Irinotecan Hydrochloride Injection and for 7 days after the final dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Irinotecan · 8.4

  “The effectiveness of irinotecan in pediatric patients has not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Irinotecan · 8.5

  “Patients greater than 65 years of age should be closely monitored because of a greater risk of early and late diarrhea in this population [see Clinical Pharmacology (12.3) and Adverse Reactions (6.1) ] .”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Irinotecan · 8.3

  “Contraception Irinotecan Hydrochloride Injection can cause fetal harm when administered to a pregnant woman.”