Cetuximab
ستوکسیماب
🎗️ Antineoplastic And Immunomodulating AgentsEGFR antagonist antibody
Market / country: 🇺🇸 USA
Erbitux (US)
🧮 Dose calculator
Colorectal cancer · Regimen source: FDA Erbitux · 2.2FDA Erbitux · 2.3
- • Only under an oncologist; continue until progression or unacceptable toxicity. Dose adjustments for toxicity and interactions per label. FDA Erbitux · 2.3
Enter age and weight.
🛡️ Safety & information
Warnings
- • Boxed warning: serious and fatal infusion reactions; cardiopulmonary arrest or sudden death (monitor electrolytes). FDA Erbitux · Boxed Warning
- • Pulmonary toxicity; dermatologic toxicity; hypomagnesaemia; increased progression and mortality in RAS-mutant disease; embryo-fetal toxicity. FDA Erbitux · 5
Formulations
- 2 mg/mL (100 mg/50 mL, 200 mg/100 mL) — injection 🇺🇸 USA FDA Erbitux · 3
👥 Special populations
- 🤰 PregnancyDangerous / avoid
Label: can cause fetal harm. Dangerous in pregnancy. FDA Erbitux · 8.1
“Risk Summary Based on findings from animal studies and its mechanism of action [see Clinical Pharmacology ( 12.1 )] , ERBITUX can cause fetal harm when administered to a pregnant woman.”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Erbitux · 8.2
“Due to the potential for serious adverse reactions in breastfed infants from ERBITUX, advise women not to breastfeed during treatment with ERBITUX and for 2 months after the last dose of ERBITUX.”
- 👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Erbitux · 8.4
“The safety and effectiveness of ERBITUX in pediatric patients have not been established.”
- 👴 Older adultsNo specific problem stated
Label: no specific difference or dose adjustment stated for older adults. FDA Erbitux · 8.5
“No overall differences in safety or efficacy were observed between these patients and younger patients.”
- ⚥ Females & males of reproductive potentialUse with caution
Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Erbitux · 8.3
“Contraception Based on its mechanism of action, ERBITUX can cause harm to the fetus when administered to a pregnant woman [see Use in Specific Populations ( 8.1 )] .”
🔗 Reference links
- FDA (approval record)BLA125084
- DailyMed (FDA label)FDA Erbitux
- MedlinePlus (NIH)Cetuximab Injection
- WHO ATC/DDDL01FE01
- Darooyab (Iran)Cetuximab
🇮🇷 Registered in Iran Darooyab · G-966/Cetuximab
Dosage forms with Iranian generic codes, per Darooyab.
- 04258 · CETUXIMAB 100MG/50ML VIAL · ویال ستوکسیمب ۱۰۰ میلیگرم / ۵۰ میلیلیتر
- 15691 · CETUXIMAB 5MG/ML 20ML VIAL · ویال ستوکسیمب ۵ میلیگرم / میلیلیتر ۲۰ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Erbitux · 3FDA Erbitux · 2.2FDA Erbitux · 2.3FDA Erbitux · Boxed WarningFDA Erbitux · 5FDA Erbitux · SPL approval / marketing categoryFDA Erbitux · 8.1FDA Erbitux · 8.2FDA Erbitux · 8.4FDA Erbitux · 8.5FDA Erbitux · 8.3
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-966/Cetuximab
- Clinical review⚠ Unverified