Cetuximab

ستوکسیماب

⚠ Unverified

🎗️ Antineoplastic And Immunomodulating AgentsEGFR antagonist antibody

Market / country: 🇺🇸 USA

Erbitux (US)

🧮 Dose calculator

Colorectal cancer · Regimen source: FDA Erbitux · 2.2FDA Erbitux · 2.3

  • • Only under an oncologist; continue until progression or unacceptable toxicity. Dose adjustments for toxicity and interactions per label. FDA Erbitux · 2.3

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🛡️ Safety & information

Warnings

  • • Boxed warning: serious and fatal infusion reactions; cardiopulmonary arrest or sudden death (monitor electrolytes). FDA Erbitux · Boxed Warning
  • • Pulmonary toxicity; dermatologic toxicity; hypomagnesaemia; increased progression and mortality in RAS-mutant disease; embryo-fetal toxicity. FDA Erbitux · 5

Formulations

  • 2 mg/mL (100 mg/50 mL, 200 mg/100 mL) — injection 🇺🇸 USA FDA Erbitux · 3

👥 Special populations

  • 🤰 PregnancyDangerous / avoid

    Label: can cause fetal harm. Dangerous in pregnancy. FDA Erbitux · 8.1

    “Risk Summary Based on findings from animal studies and its mechanism of action [see Clinical Pharmacology ( 12.1 )] , ERBITUX can cause fetal harm when administered to a pregnant woman.”
  • 🤱 BreastfeedingDangerous / avoid

    Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Erbitux · 8.2

    “Due to the potential for serious adverse reactions in breastfed infants from ERBITUX, advise women not to breastfeed during treatment with ERBITUX and for 2 months after the last dose of ERBITUX.”
  • 👶 ChildrenSafety not established

    Label: safety and effectiveness in children have not been established. FDA Erbitux · 8.4

    “The safety and effectiveness of ERBITUX in pediatric patients have not been established.”
  • 👴 Older adultsNo specific problem stated

    Label: no specific difference or dose adjustment stated for older adults. FDA Erbitux · 8.5

    “No overall differences in safety or efficacy were observed between these patients and younger patients.”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Erbitux · 8.3

    “Contraception Based on its mechanism of action, ERBITUX can cause harm to the fetus when administered to a pregnant woman [see Use in Specific Populations ( 8.1 )] .”

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