Mercaptopurine

🧮 Dose calculator

Acute lymphoblastic leukaemia (ALL) · Regimen source: FDA Mercaptopurine susp · 2.1

• • Equals 50–75 mg/m². Adjust to ANC. Homozygous TPMT/NUDT15 deficiency: ≤10%. With allopurinol one-third to one-quarter. CrCl <50 or hepatic impairment: lowest dose or every 36–48 h. FDA Mercaptopurine susp · 2.1FDA Mercaptopurine susp · 2.2FDA Mercaptopurine susp · 2.4FDA Mercaptopurine susp · 2.3

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Mercaptopurine susp · 8.1

  “Risk Summary Mercaptopurine can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Mercaptopurine susp · 8.2

  “Because of the potential for serious adverse reactions in the breastfed child, advise women not to breastfeed during treatment with mercaptopurine and for 1 week after the last dose.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Mercaptopurine susp · 8.4

  “Safety and effectiveness of mercaptopurine have been established in pediatric patients.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Mercaptopurine susp · 8.5

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or another drug therapy.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Mercaptopurine susp · 8.3

  “Contraception Females Advise females of reproductive potential to use effective contraception during treatment with mercaptopurine and for 6 months after the last dose.”