Tapentadol

🧮 Dose calculator

Severe pain requiring an opioid · Regimen source: FDA Nucynta · 2.3

• • Day 1: the second dose may be given 1 h after the first. Over 700 mg on day 1 and 600 mg thereafter not studied. The calculator shows 6-hourly. FDA Nucynta · 2.3
• • Moderate hepatic impairment: 50 mg no more often than every 8 h; severe: not recommended. FDA Nucynta · 2.5

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Nucynta · Boxed Warning

  “( 5.2 ) Advise pregnant women using opioids for an extended period of time of the risk of Neonatal Opioid Withdrawal Syndrome, which may be life-threatening if not recognized and treated.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Nucynta · 8.2

  “Risk Summary There are no data on the presence of tapentadol in human milk, the effects on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenUse with caution

  Label: only ≥6 years weighing at least 40 kg. Accidental ingestion by a child can be fatal. FDA Nucynta · 8.4

  “The safety and effectiveness of NUCYNTA (tapentadol) tablets in pediatric patients ages 6 years and older who weigh at least 40 kg have been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Nucynta · 8.5

  “In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Nucynta · 8.3

  “Infertility Use of opioids for an extended period of time may cause reduced fertility in females and males of reproductive potential.”