Oxycodone

اکسی‌کدون

⚠ Unverified

🧠 Nervous SystemOpioid agonist

Market / country: 🇺🇸 USA

Roxicodone (US)

🧮 Dose calculator

Severe pain requiring an opioid · Regimen source: FDA Oxycodone IR · 2.3

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🛡️ Safety & information

Contraindications

  • ⛔ Significant respiratory depression; acute or severe asthma without monitoring; GI obstruction or paralytic ileus; hypersensitivity. FDA Oxycodone IR · 4

Warnings

  • • Boxed warning: addiction and misuse, life-threatening respiratory depression, accidental ingestion in children, neonatal opioid withdrawal, interactions with benzodiazepines and CYP3A4 inhibitors. Keep naloxone available. FDA Oxycodone IR · Boxed WarningFDA Oxycodone IR · 2.2

Formulations

👥 Special populations

  • 🤰 PregnancyDangerous / avoid

    Label: can cause fetal harm. Dangerous in pregnancy. FDA Oxycodone IR · Boxed Warning

    “Neonatal Opioid Withdrawal Syndrome (NOWS) Advise pregnant women using opioids for an extended period of time of the risk of Neonatal Opioid Withdrawal Syndrome , which may be life-threatening if not recognized and treated.”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Oxycodone IR · 8.2

    “Risk Summary Available data from lactation studies indicate that oxycodone is present in breastmilk and that doses of less than 60 mg/day of the immediate-release formulation are unlikely to result in clinically relevant exposures in breastfed infants.”
  • 👶 ChildrenSafety not established

    Label: not evaluated in children. Accidental ingestion of even one dose by a child can be fatal. FDA Oxycodone IR · 8.4

    “The safety and efficacy of oxycodone hydrochloride tablets in pediatric patients have not been evaluated.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Oxycodone IR · 8.5

    “In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Oxycodone IR · 8.3

    “Infertility Use of opioids for an extended period of time may cause reduced fertility in females and males of reproductive potential.”

📚 Reference status for this drug

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