Palonosetron
پالونوسترون
🍽️ Alimentary Tract And MetabolismLong-acting 5-HT3 antagonist
Market / country: 🇺🇸 USA
Aloxi (US)
🧮 Dose calculator
Chemotherapy-induced nausea and vomiting · Regimen source: FDA Palonosetron · 2.1, Table 1
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to palonosetron. FDA Palonosetron · 4
Warnings
- • Hypersensitivity (including in those allergic to other 5-HT3 antagonists); serotonin syndrome. FDA Palonosetron · 5
Formulations
- 0.05 mg/mL (0.25 mg/5 mL) vial — injection 🇺🇸 USA FDA Palonosetron · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Palonosetron · 8.1
“Risk Summary There are no available data on palonosetron HCl use in pregnant women to inform a drug-associated risk.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Palonosetron · 8.2
“Risk Summary There are no data on the presence of palonosetron in human milk, the effects of palonosetron on the breastfed infant, or the effects of palonosetron on milk production.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Palonosetron · 8.4
“Chemotherapy-Induced Nausea and Vomiting Safety and effectiveness of palonosetron hydrochloride injection have been established in pediatric patients aged 1 month to less than 17 years for the prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, …”
- 👴 Older adultsNo specific problem stated
Label: no specific difference or dose adjustment stated for older adults. FDA Palonosetron · 8.5
“No dose adjustment is required for geriatric patients.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA201533
- DailyMed (FDA label)FDA Palonosetron
- MedlinePlus (NIH)Palonosetron Injection
- WHO ATC/DDDA04AA05
- Darooyab (Iran)Palonosetron
🇮🇷 Not found in Iran list Darooyab · G-2624/Palonosetron
Darooyab lists no registered dosage form or brand for this drug. This does not prove it is unavailable.
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Palonosetron · 3FDA Palonosetron · 2.1, Table 1FDA Palonosetron · 2.1FDA Palonosetron · 4FDA Palonosetron · 5FDA Palonosetron · 8.1FDA Palonosetron · 8.2FDA Palonosetron · 8.4FDA Palonosetron · 8.5FDA Palonosetron · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-2624/Palonosetron
- Clinical review⚠ Unverified