Metolazone
متولازون
❤️ Cardiovascular SystemThiazide-like diuretic
Market / country: 🇺🇸 USA
Zaroxolyn (US)
🧮 Dose calculator
Edema · Regimen source: FDA Metolazone · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Anuria; hepatic coma or pre-coma; hypersensitivity to metolazone. FDA Metolazone · Contraindications
Formulations
- 2.5 mg tablet — tablet 🇺🇸 USA FDA Metolazone · How Supplied
- 5 mg tablet — tablet 🇺🇸 USA FDA Metolazone · How Supplied
- 10 mg tablet — tablet 🇺🇸 USA FDA Metolazone · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Metolazone · Precautions/Warnings – Pregnancy
“Teratogenic Effects Pregnancy Category B Reproduction studies performed in mice, rabbits, and rats treated during the appropriate period of gestation at doses up to 50 mg/kg/day have revealed no evidence of harm to the fetus due to metolazone.”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Metolazone · Precautions/Warnings – Nursing Mothers
“Because of the potential for serious adverse reactions in nursing infants from metolazone, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.”
- 👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Metolazone · Precautions/Warnings – Pediatric Use
“Safety and effectiveness in pediatric patients have not been established in controlled clinical trials.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Metolazone · Precautions/Warnings – Geriatric Use
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA213827
- DailyMed (FDA label)FDA Metolazone
- MedlinePlus (NIH)Metolazone
- WHO ATC/DDDC03BA08
- Darooyab (Iran)Metolazone
🇮🇷 Registered in Iran Darooyab · G-1766/Metolazone
Dosage forms with Iranian generic codes, per Darooyab.
- 08667 · METOLAZONE 5MG TAB · قرص متولازون ۵ میلیگرم
- 52021 · METOLAZONE TABLET ORAL 10 mg · قرص متولازون ۱۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Metolazone · How SuppliedFDA Metolazone · Dosage and AdministrationFDA Metolazone · ContraindicationsFDA Metolazone · Precautions/Warnings – PregnancyFDA Metolazone · Precautions/Warnings – Nursing MothersFDA Metolazone · Precautions/Warnings – Pediatric UseFDA Metolazone · Precautions/Warnings – Geriatric UseFDA Metolazone · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-1766/Metolazone
- Clinical review⚠ Unverified