Isavuconazonium (isavuconazole)

🧮 Dose calculator

Mucormycosis · Regimen source: FDA Cresemba · 2.2, Table 1

• • Loading: 372 mg every 8 h for 6 doses (48 h), then once daily maintenance starting 12–24 h after the last loading dose. 372 mg isavuconazonium = 200 mg isavuconazole. FDA Cresemba · 2.2, Table 1

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Cresemba · 8.1

  “Risk Summary Based on findings from animal studies, CRESEMBA may cause fetal harm when administered to a pregnant woman.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Cresemba · 8.2

  “Risk Summary There are no data on the presence of isavuconazole in human milk, the effects on the breastfed infant or the effects on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Cresemba · 8.4

  “Invasive Aspergillosis The safety and effectiveness of CRESEMBA for injection for the treatment of invasive aspergillosis have been established in pediatric patients 1 year of age and older.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Cresemba · 8.5

  “No dose adjustment of CRESEMBA is needed in elderly patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Cresemba · 8.3

  “Contraception CRESEMBA may cause embryo-fetal harm when administered to pregnant women [see Warnings and Precautions ( 5.4 ) and Use in Specific Populations ( 8.1 )].”