Voriconazole (IV)

🧮 Dose calculator

Invasive fungal infection (aspergillosis, candidaemia, cryptococcosis) — hospital · Regimen source: FDA Vfend IV · 2.3, Table 1

• • Loading: 6 mg/kg every 12 h for the first 24 h. Candidaemia: 3–4 mg/kg. At least 7 days IV, then oral 200 mg every 12 h (half if <40 kg). Infuse over 1–3 h, max 3 mg/kg/h; never as a bolus. 12–14 y weighing ≥50 kg: adult dose. FDA Vfend IV · 2.3FDA Vfend IV · 2.1FDA Vfend IV · 2.4

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Vfend IV · 8.1

  “Risk Summary Voriconazole can cause fetal harm when administered to a pregnant woman.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Vfend IV · 8.2

  “Risk Summary No data are available regarding the presence of voriconazole in human milk, the effects of voriconazole on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Vfend IV · 8.4

  “The safety and effectiveness of VFEND have been established in pediatric patients 2 years of age and older based on evidence from adequate and well-controlled studies in adult and pediatric patients and additional pediatric pharmacokinetic and safety data.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Vfend IV · 8.5

  “However, the overall safety profile of the elderly patients was similar to that of the young so no dosage adjustment is recommended [see Clinical Pharmacology (12.3) ] .”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Vfend IV · 8.3

  “Contraception Advise females of reproductive potential to use effective contraception during treatment with VFEND.”