Eltrombopag

🧮 Dose calculator

Immune thrombocytopenia (ITP) · Regimen source: FDA Promacta · 2.1

• • East-/Southeast-Asian ancestry or hepatic impairment: start 25 mg. Target platelets ≥50×10⁹/L, not normalisation. FDA Promacta · 2.1
• • Fasting or with a low-calcium meal; 2 h before or 4 h after antacids, dairy and iron/calcium/zinc supplements. FDA Promacta · 2.4

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Promacta · 8.1

  “Risk Summary Available data from a small number of published case reports and postmarketing experience with PROMACTA use in pregnant women are insufficient to assess any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Promacta · 8.2

  “Due to the potential for serious adverse reactions in a breastfed child from PROMACTA, breastfeeding is not recommended during treatment.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Promacta · 8.4

  “The safety and efficacy of PROMACTA have been established in pediatric patients 1 year and older with persistent or chronic ITP and in pediatric patients 2 years and older with IST-naïve severe aplastic anemia (in combination with h-ATG and cyclosporine).”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Promacta · 8.5

  “No overall differences in safety or effectiveness were observed between these patients and younger patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Promacta · 8.3

  “Contraception Based on animal reproduction studies, PROMACTA can cause fetal harm when administered to a pregnant woman.”