Ribavirin

ریباویرین

⚠ Unverified

🦠 Antiinfectives For Systemic UseNucleoside analogue antiviral

Market / country: 🇺🇸 USA

Rebetol (US)

🧮 Dose calculator

Chronic hepatitis C · Regimen source: FDA Ribavirin caps · 2.2FDA Ribavirin caps · 2.3FDA Ribavirin caps · 2.1FDA Ribavirin caps · 2.5

⛔ Dose from the label weight table (with PegIntron or Intron A); with food; do not open or crush. Not effective alone for HCV. Reduce for anaemia/adverse reactions per Table 4. FDA Ribavirin caps · 2.2FDA Ribavirin caps · 2.3FDA Ribavirin caps · 2.1FDA Ribavirin caps · 2.5

🛡️ Safety & information

Contraindications

  • ⛔ Pregnancy and male partners of pregnant women; haemoglobinopathies (thalassaemia major, sickle-cell); autoimmune hepatitis; decompensated liver disease; CrCl <50; didanosine. FDA Ribavirin caps · 4

Warnings

  • • Boxed warning: severe embryo-fetal toxicity (contraception until 6 months after treatment for women and men); haemolytic anaemia; ineffective alone. FDA Ribavirin caps · Boxed Warning

Formulations

👥 Special populations

  • 🤰 PregnancyContraindicated

    Label: contraindicated in pregnancy. FDA Ribavirin caps · 4

    “Ribavirin capsules combination therapy is contraindicated in: pregnancy.”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Ribavirin caps · 8.2

    “Risk Summary There are no data on the presence of ribavirin in human milk or the effects on the breastfed infant or milk production.”
  • 👶 ChildrenUse with caution

    The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Ribavirin caps · 8.4

    “Safety and effectiveness of ribavirin in combination with PegIntron has not been established in pediatric patients below the age of 3 years.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Ribavirin caps · 8.5

    “In general, ribavirin capsules should be administered to elderly patients cautiously, starting at the lower end of the dosing range, reflecting the greater frequency of decreased hepatic and cardiac function, and of concomitant disease or other drug therapy.”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Ribavirin caps · 8.3

    “Contraception Female patients of reproductive potential should use effective contraception during treatment and for 9 months post-therapy.”

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