Sofosbuvir + velpatasvir

🧮 Dose calculator

Chronic hepatitis C · Regimen source: FDA Epclusa · 2.3FDA Epclusa · 2.4, Table 2

• • Shown as the sofosbuvir component. Under 17 kg: 150/37.5 mg oral pellets. Decompensated cirrhosis: add ribavirin. Test HBsAg and anti-HBc before starting. FDA Epclusa · 2.2FDA Epclusa · 2.4FDA Epclusa · 2.1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label: contraindicated only in combination with ribavirin (pregnant women and men whose partners are pregnant); limited data for Epclusa alone. FDA Epclusa · 8.1

  “Risk Summary If EPCLUSA is administered with ribavirin, the combination regimen is contraindicated in pregnant women and in men whose female partners are pregnant.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Epclusa · 8.2

  “The predominant circulating metabolite of sofosbuvir (GS-331007) was the primary component observed in the milk of lactating rats administered sofosbuvir, without effect on nursing pups.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Epclusa · 8.4

  “The pharmacokinetics, safety, and effectiveness of EPCLUSA for treatment of HCV genotype 1, 2, 3, 4, or 6 infection in treatment-naïve and treatment-experienced pediatric patients 3 years of age and older without cirrhosis or with compensated cirrhosis have been established in an open-label, multicenter clinical trial …”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Epclusa · 8.5

  “No dosage adjustment of EPCLUSA is warranted in geriatric patients [see Clinical Pharmacology (12.3) ] .”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Epclusa · 8.3

  “If EPCLUSA is administered with ribavirin, the information for ribavirin with regard to pregnancy testing, contraception, and infertility also applies to this combination regimen.”