Desvenlafaxine

دسونلافاکسین

⚠ Unverified

🧠 Nervous SystemSNRI

Market / country: 🇺🇸 USA

Pristiq (US)

🧮 Dose calculator

Major depressive disorder · Regimen source: FDA Desvenlafaxine · 2.1

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🛡️ Safety & information

Contraindications

  • ⛔ Hypersensitivity to desvenlafaxine or venlafaxine; MAOIs concurrently or within 7 days of stopping (or 14 days after stopping an MAOI); starting in a patient on linezolid or IV methylene blue. FDA Desvenlafaxine · 4

Warnings

Renal adjustment

  • • eGFR < 50: CrCl 30–50: max 50 mg/day; CrCl <30 or ESRD: 25 mg daily or 50 mg every other day. FDA Desvenlafaxine · 2.2

Formulations

👥 Special populations

  • 🤰 PregnancyUse with caution

    Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Desvenlafaxine · 8.1

    “Risk Summary Based on data from published observational studies, exposure to SNRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions (5.4) and Clinical Considerations].”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Desvenlafaxine · 8.2

    “Risk Summary Available limited data from published literature show low levels of desvenlafaxine in human milk, and have not shown adverse reactions in breastfed infants (see Data) .”
  • 👶 ChildrenDangerous / avoid

    Boxed warning in the label about children. FDA Desvenlafaxine · Boxed Warning

    “Desvenlafaxine extended-release tablets are not approved for use in pediatric patients [see Use in Specific Populations (8.4) ] .”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Desvenlafaxine · 8.5

    “… ly significant hyponatremia in elderly patients, who may be at greater risk for this adverse event [see Warnings and Precautions (5.9) ] .”
  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

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