Desvenlafaxine
دسونلافاکسین
🧠 Nervous SystemSNRI
Market / country: 🇺🇸 USA
Pristiq (US)
🧮 Dose calculator
Major depressive disorder · Regimen source: FDA Desvenlafaxine · 2.1
- • 50 mg is both the starting and therapeutic dose; higher doses showed no extra benefit. Taper on stopping (25 mg is for tapering). FDA Desvenlafaxine · 2.1FDA Desvenlafaxine · 2.5
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to desvenlafaxine or venlafaxine; MAOIs concurrently or within 7 days of stopping (or 14 days after stopping an MAOI); starting in a patient on linezolid or IV methylene blue. FDA Desvenlafaxine · 4
Warnings
- • Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults. FDA Desvenlafaxine · Boxed Warning
- • Serotonin syndrome; raised blood pressure (monitor); bleeding with NSAIDs/aspirin/anticoagulants. FDA Desvenlafaxine · 5
Renal adjustment
- • eGFR < 50: CrCl 30–50: max 50 mg/day; CrCl <30 or ESRD: 25 mg daily or 50 mg every other day. FDA Desvenlafaxine · 2.2
Formulations
- 25 mg extended-release tablet (swallow whole) — tablet 🇺🇸 USA FDA Desvenlafaxine · 3
- 50 mg extended-release tablet (swallow whole) — tablet 🇺🇸 USA FDA Desvenlafaxine · 3
- 100 mg extended-release tablet (swallow whole) — tablet 🇺🇸 USA FDA Desvenlafaxine · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Desvenlafaxine · 8.1
“Risk Summary Based on data from published observational studies, exposure to SNRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions (5.4) and Clinical Considerations].”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Desvenlafaxine · 8.2
“Risk Summary Available limited data from published literature show low levels of desvenlafaxine in human milk, and have not shown adverse reactions in breastfed infants (see Data) .”
- 👶 ChildrenDangerous / avoid
Boxed warning in the label about children. FDA Desvenlafaxine · Boxed Warning
“Desvenlafaxine extended-release tablets are not approved for use in pediatric patients [see Use in Specific Populations (8.4) ] .”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Desvenlafaxine · 8.5
“… ly significant hyponatremia in elderly patients, who may be at greater risk for this adverse event [see Warnings and Precautions (5.9) ] .”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA204028
- DailyMed (FDA label)FDA Desvenlafaxine
- MedlinePlus (NIH)Desvenlafaxine
- WHO ATC/DDDN06AX23
- Darooyab (Iran)Desvenlafaxine
🇮🇷 Not found in Iran list Darooyab · G-4910/Desvenlafaxine
Darooyab lists no registered dosage form or brand for this drug. This does not prove it is unavailable.
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Desvenlafaxine · 3FDA Desvenlafaxine · 2.1FDA Desvenlafaxine · 2.5FDA Desvenlafaxine · 4FDA Desvenlafaxine · Boxed WarningFDA Desvenlafaxine · 5FDA Desvenlafaxine · 2.2FDA Desvenlafaxine · 8.1FDA Desvenlafaxine · 8.2FDA Desvenlafaxine · 8.5FDA Desvenlafaxine · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-4910/Desvenlafaxine
- Clinical review⚠ Unverified