Doxepin
دوکسپین
🧠 Nervous SystemTricyclic antidepressant
Market / country: 🇺🇸 USA
Sinequan (US)
🧮 Dose calculator
Major depressive disorder · Regimen source: FDA Doxepin caps. · 2.2
- • Target 75–150 mg/day; max 100 mg three times daily. FDA Doxepin caps. · 2
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to doxepin. FDA Doxepin caps. · 4
Warnings
- • Boxed warning: suicidal thoughts and behaviours in children and young adults. FDA Doxepin caps. · Boxed Warning
Formulations
- 10 mg capsule — capsule 🇺🇸 USA FDA Doxepin caps. · 3
- 25 mg capsule — capsule 🇺🇸 USA FDA Doxepin caps. · 3
- 50 mg capsule — capsule 🇺🇸 USA FDA Doxepin caps. · 3
- 75 mg capsule — capsule 🇺🇸 USA FDA Doxepin caps. · 3
- 100 mg capsule — capsule 🇺🇸 USA FDA Doxepin caps. · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Doxepin caps. · 8.1
“Risk Summary Available data from published epidemiological studies and postmarketing reports have not established an increased risk for major birth defects or miscarriage with doxepin hydrochloride capsules use (see Data).”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Doxepin caps. · 8.2
“Because of the potential for serious adverse reactions, including excess sedation and respiratory depression in a breastfed infant, advise patients that breastfeeding is not recommended during doxepin hydrochloride capsules treatment.”
- 👶 ChildrenDangerous / avoid
Boxed warning in the label about children. FDA Doxepin caps. · Boxed Warning
“Antidepressants increase the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Doxepin caps. · 8.5
“Clinical studies of doxepin did not include sufficient numbers of patients 65 years of age and older to determine whether they respond differently from younger adult patients.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA207482
- DailyMed (FDA label)FDA Doxepin caps.
- MedlinePlus (NIH)Doxepin (Depression, Anxiety)Doxepin (Insomnia)
- WHO ATC/DDDN06AA12
- Darooyab (Iran)Doxepin
🇮🇷 Registered in Iran Darooyab · G-581/Doxepin
Dosage forms with Iranian generic codes, per Darooyab.
- 00470 · DOXEPIN HCL 10MG CAP · کپسول دوکسپین هیدروکلراید ۱۰ میلیگرم
- 01995 · DOXEPIN HCL 10MG TAB · قرص دوکسپین هیدروکلراید ۱۰ میلیگرم
- 00471 · DOXEPIN HCL 25MG CAP · کپسول دوکسپین هیدروکلراید ۲۵ میلیگرم
- 01996 · DOXEPIN HCL 25MG TAB · قرص دوکسپین هیدروکلراید ۲۵ میلیگرم
- 01480 · DOXEPIN HCL 25MG/2ML AMP · آمپول دوکسپین هیدروکلراید ۲۵ میلیگرم / ۲ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Doxepin caps. · 3FDA Doxepin caps. · 2.2FDA Doxepin caps. · 2FDA Doxepin caps. · 4FDA Doxepin caps. · Boxed WarningFDA Doxepin caps. · 8.1FDA Doxepin caps. · 8.2FDA Doxepin caps. · 8.5FDA Doxepin caps. · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-581/Doxepin
- Clinical review⚠ Unverified