Vortioxetine

🧮 Dose calculator

Major depressive disorder · Regimen source: FDA Trintellix · 2.1

• • May reduce to 5 mg if not tolerated. Screen for bipolar disorder before starting. FDA Trintellix · 2.1FDA Trintellix · 2.2

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Trintellix · 8.1

  “Risk Summary Based on data from published observational studies, exposure to SSRIs or SNRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions (5.3) and Clinical Considerations ] .”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Trintellix · 8.2

  “Risk Summary There is no information regarding the presence of vortioxetine in human milk, the effects on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenDangerous / avoid

  Boxed warning in the label about children. FDA Trintellix · Boxed Warning

  “Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Trintellix · 8.5

  “Serotonergic antidepressants have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse event [see Warnings and Precautions (5.7) ] .”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.