Major depressive disorder
Major depressive disorder · ICD-10: F32.9
Symptoms
- • Depressed or irritable mood
- • Loss of interest or pleasure
- • Fatigue and lack of energy
- • Feeling hopeless, worthless or guilty
- • Sudden change in appetite and weight
- • Trouble sleeping or sleeping too much
- • Trouble concentrating
- • Becoming withdrawn
- • Thoughts of death or suicide
Drugs and regimens
Depression — adult outpatients: 75 mg/day divided
Depression — adolescents and elderly: 10 mg three times daily + 20 mg at bedtime
Under 12 years
MDD — adults: 150 mg morning, 300 after 4 days
MDD — adults: 20 mg daily (max 40)
Children
Major depression — 40–60 mg/day
MDD — ≥12 years: 10 mg daily (max 20)
MDD — children/adolescents (≥8 y): start 10 or 20 mg
MDD — adults: 20 mg in the morning
Depression — adult outpatients: 75 mg/day (up to 150)
MDD — adults: 15 mg at night (max 45)
Depression — adults: 25 mg three or four times daily
Adolescents and elderly: 30–50 mg/day
Major depression — 20 mg daily (max 50)
Bipolar depression — adults: 50 mg at bedtime, target 300
MDD — adults: start 50 mg
MDD — adults: 150 mg/day divided
MDD — adults: 75 mg daily