Ceftolozane-tazobactam

🧮 Dose calculator

Complicated intra-abdominal infection and peritonitis · Regimen source: FDA Zerbaxa · 2.1, Table 1

• • Dose as total ceftolozane + tazobactam (2:1). 1-hour infusion every 8 h. cIAI with metronidazole. FDA Zerbaxa · 2.1

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Zerbaxa · 8.1

  “Risk Summary There are no data available on ZERBAXA, ceftolozane or tazobactam use in pregnant women to allow assessment of a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Zerbaxa · 8.2

  “Risk Summary There are no data on the presence of ceftolozane or tazobactam in human milk.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Zerbaxa · 8.4

  “The safety and effectiveness of ZERBAXA for the treatment of cIAI, cUTI, and HABP/VABP have been established in pediatric patients at least 32 weeks gestational age and older.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Zerbaxa · 8.5

  “Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.