Plecanatide

🧮 Dose calculator

Chronic idiopathic constipation · Regimen source: FDA Trulance · 2.1

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👥 Special populations

• 🤰 PregnancyNo specific problem stated

  Label: minimal systemic absorption; fetal exposure not expected. FDA Trulance · 8.1

  “Risk Summary Plecanatide and its active metabolite are negligibly absorbed systemically following oral administration [see Clinical Pharmacology (12.3) ] and maternal use is not expected to result in fetal exposure to the drug.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Trulance · 8.2

  “Risk Summary After administration of multiple doses of TRULANCE 3 mg once daily for 2 weeks to nursing mothers, plecanatide and its active metabolite were not measurable in breast milk collected at 2 hours, 6 hours, and 12 hours post-dosing.”

• 👶 ChildrenContraindicated

  Label: contraindicated in children below a stated age. FDA Trulance · 4

  “TRULANCE is contraindicated in: Patients less than 6 years of age due to the risk of serious dehydration [see Warnings and Precautions (5.1) , Use in Specific Populations (8.4) ] .”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Trulance · 8.5

  “Chronic Idiopathic Constipation (CIC) Of 2,601 subjects in placebo-controlled clinical trials of TRULANCE, 273 (10%) were 65 years of age and over, and 47 (2%) were 75 years and over.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.