Alosetron

آلوسترون

⚠ Unverified

🍽️ Alimentary Tract And Metabolism5-HT3 antagonist

Market / country: 🇺🇸 USA

Lotronex (US)

🧮 Dose calculator

Functional bowel / irritable bowel syndrome · Regimen source: FDA Alosetron · 2.1

  • • Stop at once if constipated; after resolution restart at 0.5 mg once daily; stop permanently if it recurs. Stop if not controlled after 4 weeks at 1 mg twice daily. FDA Alosetron · 2.1

Enter age (weight is optional for this regimen).

🛡️ Safety & information

Contraindications

  • ⛔ Current constipation; history of severe constipation or its sequelae, obstruction, stricture, toxic megacolon, perforation or adhesions; ischaemic colitis, impaired intestinal circulation, thrombophlebitis or hypercoagulable state; Crohn disease or ulcerative colitis; diverticulitis; severe hepatic impairment; fluvoxamine. FDA Alosetron · 4

Warnings

  • • Boxed warning: serious GI adverse reactions (ischaemic colitis, complications of constipation) sometimes requiring surgery or causing death — only for women with severe refractory IBS-D; stop immediately with constipation or rectal bleeding. FDA Alosetron · Boxed Warning

Formulations

👥 Special populations

  • 🤰 PregnancyUse with caution

    Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Alosetron · 8.1

    “Risk Summary The available data with alosetron tablets use in pregnant women are insufficient to draw conclusions about any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes.”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Alosetron · 8.2

    “Risk Summary There are no data regarding the presence of alosetron in human milk, the effects on the breastfed infant, or the effects on milk production.”
  • 👶 ChildrenSafety not established

    Label: safety and effectiveness in children have not been established. FDA Alosetron · 8.4

    “Safety and effectiveness in pediatric patients have not been established.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Alosetron · 8.5

    “In some studies in healthy men or women, plasma concentrations were elevated by approximately 40% in individuals 65 years and older compared to young adults [see Warnings and Precautions ( 5.1 )] .”
  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

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