Prucalopride
پروکالوپراید
🍽️ Alimentary Tract And Metabolism5-HT4 receptor agonist
Market / country: 🇺🇸 USA
Motegrity (US)
🧮 Dose calculator
Chronic idiopathic constipation · Regimen source: FDA Motegrity · 2
- • CrCl <30: 1 mg once daily. FDA Motegrity · 2
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity; intestinal perforation or obstruction, obstructive ileus, severe IBD (Crohn’s, colitis, toxic megacolon). FDA Motegrity · 4
Formulations
- 1 mg tablet — tablet 🇺🇸 USA FDA Motegrity · 3
- 2 mg tablet — tablet 🇺🇸 USA FDA Motegrity · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Motegrity · 8.1
“Risk Summary Available data from case reports with prucalopride use in pregnant women are insufficient to identify any drug-associated risks of miscarriage, major birth defects, or adverse maternal or fetal outcomes.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Motegrity · 8.2
“Risk Summary Prucalopride is present in breast milk (see Data ) .”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Motegrity · 8.4
“The safety and effectiveness of MOTEGRITY have not been established in pediatric patients.”
- 👴 Older adultsNo specific problem stated
Label: no specific difference or dose adjustment stated for older adults. FDA Motegrity · 8.5
“No overall differences in safety and effectiveness were observed between elderly and younger patients.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA210166
- DailyMed (FDA label)FDA Motegrity
- MedlinePlus (NIH)Prucalopride
- WHO ATC/DDDA06AX05
- Darooyab (Iran)Prucalopride
🇮🇷 Registered in Iran Darooyab · G-4792/Prucalopride
Dosage forms with Iranian generic codes, per Darooyab.
- 17328 · PRUCALOPRIDE 2MG TAB · قرص پروکالوپراید ۲ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Motegrity · 3FDA Motegrity · 2FDA Motegrity · 4FDA Motegrity · SPL approval / marketing categoryFDA Motegrity · 8.1FDA Motegrity · 8.2FDA Motegrity · 8.4FDA Motegrity · 8.5
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-4792/Prucalopride
- Clinical review⚠ Unverified