Mannitol
مانیتول
🩸 Blood And Blood Forming OrgansOsmotic diuretic
Market / country: 🇺🇸 USA
Osmitrol (US)
🧮 Dose calculator
Raised intracranial pressure and cerebral oedema · Regimen source: FDA Osmitrol · 2.2
- • Preferably a central vein. Assess renal, cardiac and pulmonary status and correct electrolytes first; monitor osmolality. Not with blood products in the same set. FDA Osmitrol · 2.1FDA Osmitrol · 2.2
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to mannitol; anuria; severe hypovolaemia; severe pulmonary congestion or oedema; active intracranial bleeding (except during craniotomy). FDA Osmitrol · 4
Warnings
- • Renal failure; CNS toxicity; fluid/electrolyte imbalance and hyperosmolarity; infusion-site reactions. FDA Osmitrol · 5
Formulations
- 20% (0.2 g/mL) 250/500 mL bag — injection 🇺🇸 USA FDA Osmitrol · 3
- 10% (0.1 g/mL) 500 mL bag — injection 🇺🇸 USA FDA Osmitrol · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Osmitrol · 8.1
“Risk Summary The available case report data with mannitol over decades of use have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Osmitrol · 8.2
“Risk Summary There are no data on the presence of mannitol in either human or animal milk, the effects on the breastfed infant, or the effects on milk production.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Osmitrol · 8.4
“OSMITROL is approved for use in the pediatric population for the reduction of intracranial and intraocular pressure.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Osmitrol · 8.5
“Evaluate the renal, cardiac and pulmonary status of the patient and correct fluid and electrolyte imbalances prior to administration of OSMITROL [see Warnings and Precautions (5.2 , 5.3 , 5.4 , 5.5 )].”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA013684
- DailyMed (FDA label)FDA Osmitrol
- MedlinePlus (NIH)❌ None
- WHO ATC/DDDB05BC01
- Darooyab (Iran)Mannitol
🇮🇷 Registered in Iran Darooyab · G-1747/Mannitol
Dosage forms with Iranian generic codes, per Darooyab.
- 00781 · MANNITOL 10% 0.5L INF · محلول انفوزیون مانیتول ۱۰ درصد ۰٫۵ لیتر
- 12328 · MANNITOL 10% 1L INF · محلول انفوزیون مانیتول ۱۰ درصد ۱ لیتر
- 21599 · MANNITOL 10% 250ML INF · محلول انفوزیون مانیتول ۱۰ درصد ۲۵۰ میلیلیتر
- 00782 · MANNITOL 20% 0.5L INF · محلول انفوزیون مانیتول ۲۰ درصد ۰٫۵ لیتر
- 12327 · MANNITOL 20% 1L INF · محلول انفوزیون مانیتول ۲۰ درصد ۱ لیتر
- 08804 · MANNITOL 20% 250ML INF · محلول انفوزیون مانیتول ۲۰ درصد ۲۵۰ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Osmitrol · 3FDA Osmitrol · 2.2FDA Osmitrol · 2.1FDA Osmitrol · 4FDA Osmitrol · 5FDA Osmitrol · SPL approval / marketing categoryFDA Osmitrol · 8.1FDA Osmitrol · 8.2FDA Osmitrol · 8.4FDA Osmitrol · 8.5
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-1747/Mannitol
- Clinical review⚠ Unverified