Inclisiran

🧮 Dose calculator

Hyperlipidemia / heterozygous familial hypercholesterolemia · Regimen source: FDA Leqvio · 2.1

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Leqvio · 8.1

  “… us decreasing cholesterol and possibly other biologically active substances derived from cholesterol; therefore, LEQVIO may cause fetal harm when administered to pregnant patients based on the mechanism of action [see Clinical Pharmacology (12.1)] .”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Leqvio · 8.2

  “Risk Summary There is no information on the presence of inclisiran in human milk, the effects on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Leqvio · 8.4

  “The safety and effectiveness of LEQVIO as an adjunct to diet and other LDL-C-lowering therapies for the treatment of HeFH have been established in pediatric patients aged 12 years and older.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Leqvio · 8.5

  “No overall differences in safety or effectiveness were observed between patients 65 years of age and older and younger adult patients.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.