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Fludarabine

فلودارابین

⚠ Unverified

🎗️ Antineoplastic And Immunomodulating AgentsPurine antimetabolite

🤰 Pregnancy:Dangerous / avoid 🇮🇷 Registered in Iran 🇺🇸 FDA approved generic (ANDA) ANDA220196 ATC L01BB05

Market / country: 🇺🇸 USA

Fludara (US)

🧮 Dose calculator

Disease / regimen

Chronic lymphocytic leukaemia (CLL) · Regimen source: FDA Fludarabine · 2.1

• Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Fludarabine · 2.1

Formulation

Age *

Weight (kg) *

Enter age and weight.

🛡️ Safety & information

Warnings

• Dose-dependent neurotoxicity (coma, seizures); myelosuppression; autoimmune cytopenias; transfusion-associated GVHD (irradiated blood only); tumour lysis syndrome; pulmonary toxicity with pentostatin; no live vaccines; embryo-fetal toxicity. FDA Fludarabine · 5

Renal adjustment

• eGFR < 80: CrCl 50–79: 20 mg/m²; 30–49: 15 mg/m²; under 30: per Table 1. FDA Fludarabine · 2.2, Table 1

Formulations

25 mg/mL, 50 mg/2 mL vial — injection 🇺🇸 USA FDA Fludarabine · 3

👥 Special populations

🤰 PregnancyDangerous / avoid
Label: can cause fetal harm; effective contraception required. FDA Fludarabine · 5.8
“Can cause fetal harm. Advise patients of the potential risk to a fetus and to use effective contraception.”
🤱 BreastfeedingNo data
The source for this drug has no section for this group.
👶 ChildrenNo data
The source for this drug has no section for this group.
👴 Older adultsNo data
The source for this drug has no section for this group.
⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.

🔗 Reference links

FDA (approval record)ANDA220196
DailyMed (FDA label)FDA Fludarabine
MedlinePlus (NIH)Fludarabine Injection
WHO ATC/DDDL01BB05
Darooyab (Iran)Fludarabine

🇮🇷 Registered in Iran Darooyab · G-1002/Fludarabine

Dosage forms with Iranian generic codes, per Darooyab.

00542 · FLUDARABINE PHOSPHATE 50MG VIAL · ویال فلودارابین فسفات ۵۰ میلی‌گرم
52342 · FLUDARABINE PHOSPHATE INJECTION, SOLUTION PARENTERAL 25 mg/1mL 2 mL · محلول تزریقی فلودارابین فسفات ۲۵ میلی‌گرم / ۱ میلی‌لیتر ۲ میلی‌لیتر

📚 Reference status for this drug

Shows which sources have references recorded for this drug and which do not.

FDA label (DailyMed)✅ Present
FDA Fludarabine · 3 FDA Fludarabine · 2.1 FDA Fludarabine · 5 FDA Fludarabine · 2.2, Table 1 FDA Fludarabine · 5.8 FDA Fludarabine · SPL approval / marketing category
UK SmPC (eMC / MHRA)❌ Not present
Published guideline❌ Not present
Licensed reference (medical school)❌ Not present
Iranian leaflet (IFDA)❌ Not present
Pharmacy website (secondary, unreliable)✅ Present
Darooyab · G-1002/Fludarabine
Clinical review⚠ Unverified