Bendamustine

🧮 Dose calculator

Chronic lymphocytic leukaemia (CLL) · Regimen source: FDA Bendeka · 2.1

• • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Bendeka · 2.1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm; effective contraception required. FDA Bendeka · 5.10

  “Can cause fetal harm. Advise females of reproductive potential and males with female partners of reproductive potential of the potential risk to a fetus and to use an effective method of contraception.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Bendeka · 8.2

  “Because of the potential for serious adverse reactions in the breastfed child, advise patients that breastfeeding is not recommended during treatment with BENDEKA, and for 1 week after the last dose.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Bendeka · 8.4

  “Safety and effectiveness in pediatric patients have not been established.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Bendeka · 8.5

  “No overall differences in safety were observed between patients ≥65 years of age and younger patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Bendeka · 8.3

  “Contraception Females Advise female patients of reproductive potential to use effective contraception during treatment with BENDEKA and for 6 months after the last dose.”