Efavirenz

🧮 Dose calculator

HIV-1 infection (treatment) · Regimen source: FDA Efavirenz · 2.2FDA Efavirenz · 2.3

• • Always with other antiretrovirals (unless a complete regimen). FDA Efavirenz · 2.2
• • With rifampin (≥50 kg): 800 mg. With voriconazole: efavirenz 300 mg and voriconazole 400 mg every 12 h. Not recommended in moderate/severe hepatic impairment. FDA Efavirenz · 2FDA Efavirenz · 2.1

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Efavirenz · 8.1

  “Risk Summary There are retrospective case reports of neural tube defects in infants whose mothers were exposed to efavirenz-containing regimens in the first trimester of pregnancy.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Efavirenz · 8.2

  “Because of the potential for HIV transmission in breastfed infants, advise women not to breastfeed.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Efavirenz · 8.4

  “The safety, pharmacokinetic profile, and virologic and immunologic responses of efavirenz were evaluated in antiretroviral-naive and -experienced HIV-1 infected pediatric patients 3 months to 21 years of age in three open-label clinical trials [see Adverse Reactions ( 6.2 ), Clinical Pharmacology ( 12.3 ), and …”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Efavirenz · 8.5

  “In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other therapy.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Efavirenz · 8.3

  “Contraception Females of reproductive potential should use effective contraception during treatment with efavirenz and for 12 weeks after discontinuing efavirenz due to the long half-life of efavirenz.”