Daratumumab

🧮 Dose calculator

Multiple myeloma · Regimen source: FDA Darzalex · 2.2

• • Only under an oncologist; continue until progression or unacceptable toxicity. Dose adjustments for toxicity and interactions per label. FDA Darzalex · 2.2
• • Premedicate with corticosteroid, antipyretic and antihistamine; post-infusion medicines. Type and screen before starting (cross-match interference). FDA Darzalex · 2.3FDA Darzalex · 5.2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: combination with lenalidomide, pomalidomide or thalidomide is contraindicated in pregnancy. FDA Darzalex · 8.1

  “The combination of DARZALEX and lenalidomide, pomalidomide, or thalidomide is contraindicated in pregnant women, because lenalidomide, pomalidomide, and thalidomide may cause birth defects and death of the unborn child.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Darzalex · 8.2

  “Because of the potential for serious adverse reactions in the breastfed child when DARZALEX is administered with lenalidomide, pomalidomide, or thalidomide, advise women not to breastfeed during treatment with DARZALEX.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Darzalex · 8.4

  “Safety and effectiveness of DARZALEX in pediatric patients have not been established.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Darzalex · 8.5

  “No overall differences in effectiveness were observed between these patients and younger patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Darzalex · 8.3

  “Contraception Advise females of reproductive potential to use effective contraception during treatment with DARZALEX and for 3 months after the last dose.”