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Multiple myeloma
Multiple myeloma · ICD-10: C90.00
Symptoms
- • Bone pain, mostly ribs and back
- • Fractures with normal activity
- • Fatigue and breathlessness (anaemia)
- • Frequent infections
- • Abnormal bleeding
- • Numbness or limb weakness from spinal compression
Drugs and regimens
Bortezomib⚠ Unverified
Multiple myeloma — 1.3 mg/m² IV or SC per dose (cyclical schedule)
Daratumumab⚠ Unverified
Multiple myeloma — 16 mg/kg actual body weight IV infusion; schedule by combination regimen
Lenalidomide⚠ Unverified
Multiple myeloma (combination) — 25 mg once daily on days 1–21 of 28-day cycles
Melphalan⚠ Unverified
Conditioning before autologous stem-cell transplant in multiple myeloma — 100 mg/m²/day IV over 30 min on days −3 and −2
Thalidomide⚠ Unverified
Newly diagnosed multiple myeloma (with dexamethasone) — 200 mg once daily (bedtime)