Colistimethate (colistin)
کولیستیمتات (کولیستین تزریقی)
🦠 Antiinfectives For Systemic UsePolymyxin
Market / country: 🇺🇸 USA
Coly-Mycin M (US)
🧮 Dose calculator
Sepsis / serious hospital infection (refer) · Regimen source: FDA Coly-Mycin M · Dosage and Administration
- • Based on ideal body weight. Max 5 mg/kg/day. The calculator splits into 2 doses; 3 or 4 doses are also allowed. FDA Coly-Mycin M · Dosage and Administration
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to colistimethate. FDA Coly-Mycin M · Contraindications
Warnings
- • Nephrotoxicity and neurotoxicity (paraesthesia, respiratory arrest with curariform relaxants or aminoglycosides); reduce dose in renal impairment. FDA Coly-Mycin M · Warnings
Renal adjustment
- • eGFR < 80: CrCl 50–79: 2.5–3.8 mg/kg/day in 2 doses; 30–49: 2.5 mg/kg/day once or in 2 doses; 10–29: 1.5 mg/kg every 36 h. FDA Coly-Mycin M · Dosage and Administration
Formulations
- 150 mg colistin base activity vial → 75 mg/mL after adding 2 mL water — injection 🇺🇸 USA FDA Coly-Mycin M · How SuppliedFDA Coly-Mycin M · Dosage and Administration
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Coly-Mycin M · Pregnancy - Teratogenic Effects
“Since colistimethate sodium is transferred across the placental barrier in humans, it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Coly-Mycin M · Nursing Mothers
“Therefore, caution should be exercised when colistimethate sodium is administered to nursing women.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Coly-Mycin M · Pediatric Use
“In clinical studies, colistimethate sodium was administered to the pediatric population (neonates, infants, children and adolescents).”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Coly-Mycin M · Geriatric Use
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)NDA050108
- DailyMed (FDA label)FDA Coly-Mycin M
- MedlinePlus (NIH)❌ None
- WHO ATC/DDDJ01XB01
- Darooyab (Iran)❌ None
🇮🇷 Not found in Iran list Darooyab · search
Darooyab lists no registered dosage form or brand for this drug. This does not prove it is unavailable.
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Coly-Mycin M · How SuppliedFDA Coly-Mycin M · Dosage and AdministrationFDA Coly-Mycin M · ContraindicationsFDA Coly-Mycin M · WarningsFDA Coly-Mycin M · Pregnancy - Teratogenic EffectsFDA Coly-Mycin M · Nursing MothersFDA Coly-Mycin M · Pediatric UseFDA Coly-Mycin M · Geriatric UseFDA Coly-Mycin M · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · search
- Clinical review⚠ Unverified