Sepsis / serious hospital infection (refer)

Adults, children and older infants with normal renal function — 15 mg/kg/day in 2–3 doses

Newborn — load 10 mg/kg then 7.5 mg/kg every 12 h

Child 1 month–12 y, <50 kg — 50–180 mg/kg/day in 4–6 doses

Adult — 1 g every 12 h up to 2 g every 4 h by severity

Child 1 month–12 y — 30–50 mg/kg every 8 h (max 6 g/day)

Adult — usually 1 g every 8–12 h

Adult — serious streptococcal infections: 12–24 million units/day

IV — child: 10 mg/kg every 6 h (infuse over ≥60 min)

IV — adult: 500 mg every 6 h or 1 g every 12 h