Cannabidiol

🧮 Dose calculator

Lennox-Gastaut syndrome · Regimen source: FDA Epidiolex · 2.2

• • Recommended maintenance 5 mg/kg twice daily; weekly steps of 2.5 mg/kg twice daily up to 10 mg/kg twice daily. ALT, AST and bilirubin before starting. Moderate/severe hepatic impairment per Table 1. FDA Epidiolex · 2.2FDA Epidiolex · 2.1FDA Epidiolex · 2.6

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Epidiolex · 8.1

  “… • North American Antiepileptic Drug (NAAED) Pregnancy Registry o 1-888-233-2334 o https://www.aedpregnancyregistry.org/ Risk Summary There are no adequate data on the developmental risks associated with the use of EPIDIOLEX in pregnant women.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Epidiolex · 8.2

  “Risk Summary There are no data on the presence of cannabidiol or its metabolites in human milk, the effects on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Epidiolex · 8.4

  “Safety and effectiveness of EPIDIOLEX for the treatment of seizures associated with LGS, DS, or TSC have been established in patients 1 year of age and older.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Epidiolex · 8.5

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy [see Dosage and Administration ( 2.6 ), Warnings and Precautions …”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.