Rufinamide

🧮 Dose calculator

Lennox-Gastaut syndrome · Regimen source: FDA Rufinamide susp. · 2.1

• • Increase by 10 mg/kg every other day up to 45 mg/kg/day (not over 3200 mg). With food. Start lower with valproate. FDA Rufinamide susp. · 2.1FDA Rufinamide susp. · 2.5

Enter age and weight.

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Rufinamide susp. · 8.1

  “Risk Summary There are no adequate data on the developmental risks associated with use of rufinamide in pregnant women.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Rufinamide susp. · 8.2

  “Risk Summary There are no data on the presence of rufinamide in human milk, the effects on the breastfed infant, or the effects of the drug on milk production.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Rufinamide susp. · 8.4

  “Safety and effectiveness have been established in pediatric patients 1 to 17 years of age.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Rufinamide susp. · 8.5

  “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Rufinamide susp. · 8.3

  “Contraception Use of rufinamide may reduce the effectiveness of hormonal contraceptives containing ethinyl estradiol or norethindrone.”